Unemployment Rate in De Soto County, MS was 2.40% in March of 2024, according to the United States Federal Reserve. Historically, Unemployment Rate in De Soto County, MS reached a record high of 10.20 in April of 2020 and a record low of 1.90 in May of 2001. Trading Economics provides the current actual value, an historical data chart and related indicators for Unemployment Rate in De Soto County, MS - last updated from the United States Federal Reserve on May of 2024.