De Soto County, FL - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, FL was 52.00000 Persons in January of 2022, according to the United States Federal Reserve. Historically, De Soto County, FL - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, FL reached a record high of 86.00000 in January of 2010 and a record low of 31.00000 in January of 2019. Trading Economics provides the current actual value, an historical data chart and related indicators for De Soto County, FL - Population Estimate, Total, Not Hispanic or Latino, American Indian and Alaska Native Alone (5-year estimate) in DeSoto County, FL - last updated from the United States Federal Reserve on May of 2024.