Resident Population in Pickens County, SC was 135.49500 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in Pickens County, SC reached a record high of 135.49500 in January of 2023 and a record low of 58.95600 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in Pickens County, SC - last updated from the United States Federal Reserve on May of 2024.