De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, Black or African American Alone (5-year estimate) in DeSoto County, MS was 57322.00000 Persons in January of 2022, according to the United States Federal Reserve. Historically, De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, Black or African American Alone (5-year estimate) in DeSoto County, MS reached a record high of 57322.00000 in January of 2022 and a record low of 28893.00000 in January of 2009. Trading Economics provides the current actual value, an historical data chart and related indicators for De Soto County, MS - Population Estimate, Total, Not Hispanic or Latino, Black or African American Alone (5-year estimate) in DeSoto County, MS - last updated from the United States Federal Reserve on May of 2024.