Resident Population in De Soto County, MS was 193.24700 Thous. of Persons in January of 2023, according to the United States Federal Reserve. Historically, Resident Population in De Soto County, MS reached a record high of 193.24700 in January of 2023 and a record low of 35.88500 in January of 1970. Trading Economics provides the current actual value, an historical data chart and related indicators for Resident Population in De Soto County, MS - last updated from the United States Federal Reserve on May of 2024.